| 环丙沙星中间体的合成改进 |
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| 引用本文： | 袁旭宏,李景华. 环丙沙星中间体的合成改进[J]. 重庆科技学院学报(自然科学版), 2009, 11(5): 69-70 |
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| 作者姓名： | 袁旭宏 李景华 |
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| 作者单位： | 浙江工业大学,杭州,310014;浙江工业大学,杭州,310014 |
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| 摘 要： | 对环丙沙星中间体甲酯胺化物进行了合成改进研究,由2,4-二氯-5-氟苯乙酮为原料,经氢化钠作为缩合剂,生成2,4-二氯-5-氟苯甲酰乙酸甲酯,再与硫酸二甲酯、DMF、环丙胺等反应合成甲酯胺化物.
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| 关 键 词： | 环丙沙星 甲酯胺化物 合成 |
Synthetic Improvement of Ciprofloxacin Intermediate |
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| YUAN Xu-hong,LI Jing-hua. Synthetic Improvement of Ciprofloxacin Intermediate[J]. Journal of Chongqing University of Science and Technology:Natural Science Edition, 2009, 11(5): 69-70 |
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| Authors: | YUAN Xu-hong LI Jing-hua |
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| Affiliation: | YUAN Xu-hong LI Jing-hua(Zhejiang University of Technology,Hangzhou 310014) |
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| Abstract: | The article studies the synthetic improvement of ciprofloxacin intermediate.The 2,4-dichloro-5-fluorobenzoylacetate is produced from 2,4-dichloro-5-fluoroacetophenone and the condensing agent sodium hydride,Then,the methyl propylcarboxylate amine is produced by 2,4-dichloro-5-fluorobenzoylacetate,methyl sulfate,DMF,cyclopropylamine,etc. |
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| Keywords: | ciprofloxacin methyl propylcarboxylate amine synthetic |
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