| 1-(2-羟基-5-甲基苯基)苯乙胺的合成 |
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| 引用本文： | 吴加胜,张妍,张广友. 1-(2-羟基-5-甲基苯基)苯乙胺的合成[J]. 山东化工, 2003, 0(2) |
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| 作者姓名： | 吴加胜 张妍 张广友 |
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| 作者单位： | 济南大学化学工程学院 山东济南250022(吴加胜，张妍)，济南大学化学工程学院 山东济南250022(张广友) |
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| 基金项目： | 山东省自然科学基金资助项目 (编号 :Y2 0 0 2B0 5 ) |
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| 摘 要： | 对甲基苯酚与苯乙酰氯酯化得到苯乙酸 ( 4 -甲基 )苯酯 ;然后在三氯化铝作用下重排得到苄基 ( 2 -羟基 -5 -甲基 )苯基酮 ;此酮经硫酸二甲酯甲基化得到苄基 ( 2 -甲氧基 -5 -甲基 )苯基酮 ,再和甲酸铵反应得到 1-( 2 -甲氧基 -5 -甲基苯基 )苯乙胺 ,最后经氢溴酸水解得到 1-( 2 -羟基 -5 -甲基苯基 )苯乙胺。所有中间体和最终产品的结构均由IR、元素分析、1 HNMR得到证实。
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| 关 键 词： | 对甲酚 苯乙酰氯 1-(2-羟基-5-甲基苯基)苯乙胺 |
Synthesis of 1-(2-Hydroxy-5-methylphenyl)phenethylamine |
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| WU Jia-sheng,ZHANG Yan,ZHANG Guang-you. Synthesis of 1-(2-Hydroxy-5-methylphenyl)phenethylamine[J]. Shandong Chemical Industry, 2003, 0(2) |
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| Authors: | WU Jia-sheng ZHANG Yan ZHANG Guang-you |
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| Abstract: | In this paper, p-tolyl phenylacetate was prepared from the reaction of 4-methylphenol and phenylacetyl chloride. 2-Hydroxy-5-methylphenyl benzyl actone was obstained through a rearrangement reaction using AlCl 3 as catalyst. Then hydroxy was methylated by Me 2SO 4 under PTC conditions. Then 2-methoxy-5-methylphenyl benzyl actone was aminated by HCO 2NH 4, and 1-(2-methoxy-5-methylphenyl)phenethylamine was obstained. At last, 1-(2-hydroxy-5-methylphenyl)phenethylamine was obstained by hydrosis reaction using hydrobromide. The structures of intermediate were confirmed by IR,element analysis and 1HNMR spectra. |
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| Keywords: | methylphenol phenylacetylchloride 1-(2-hydroxy-5-methylphenyl)phenethylamine |
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