‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro |
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Authors: | Alexandros Kiparissides Michalis Koutinas Cleo Kontoravdi Athanasios Mantalaris Efstratios N Pistikopoulos [Author vitae] |
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Affiliation: | aBiological Systems Engineering Laboratory, Centre for Process Systems Engineering, Imperial College London, SW7 2AZ, UK |
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Abstract: | This work presents a holistic ‘closed loop’ approach for the development of models of biological systems. The ever-increasing availability of experimental information necessitates the advancement of a systematic methodology to organise and utilise these data. Herein, we present a biological model building framework that maps the treatment of the information from the initial conception of the model, through its experimental validation and finally to its application in model-based optimisation studies. We highlight and discuss current issues associated with the development of mathematical models of biological systems and share our perspective towards a holistic ‘closed loop’ approach that will facilitate the control of the in vitro through the in silico. |
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Keywords: | Model analysis Biological systems model development Sensitivity analysis Design of experiments |
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