| 水凝胶载体应用于药物控释的数学建模进展 |
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| 引用本文： | 张妍妍,王菲,贾玉玺,王晓霞. 水凝胶载体应用于药物控释的数学建模进展[J]. 高分子材料科学与工程, 2012, 0(4): 173-176 |
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| 作者姓名： | 张妍妍 王菲 贾玉玺 王晓霞 |
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| 作者单位： | 山东大学材料液固结构演变与加工教育部重点实验室 |
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| 基金项目： | 国家自然科学基金重点项目(20734003);山东省自然科学杰出青年基金项目(JQ201016);山东大学自主创新基金项目(2009JQ013) |
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| 摘 要： | 聚合物水凝胶是由亲水性聚合物链通过物理作用或化学键作用形成的三维网络结构,在受到环境变化刺激时会产生响应性,因而作为药物控释载体广泛应用于医药领域。文中介绍了可控释药系统的类型及其主要影响因素,综述了可控释药数学模型的发展与应用,比较性分析了经验/半经验模型与机理模型,并展望了未来的发展方向。
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| 关 键 词： | 水凝胶 药物控制释放 刺激响应性 数学模型 |
Progress on Mathematical Modeling of Controlled Drug Release Using Hydrogels as Drug Carrier |
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| Yanyan Zhang,Fei Wang,Yuxi Jia,Xiaoxia Wang. Progress on Mathematical Modeling of Controlled Drug Release Using Hydrogels as Drug Carrier[J]. Polymer Materials Science & Engineering, 2012, 0(4): 173-176 |
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| Authors: | Yanyan Zhang Fei Wang Yuxi Jia Xiaoxia Wang |
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| Affiliation: | (Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials(Ministry of Education),Shandong University,Jinan 250061,China) |
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| Abstract: | Polymeric hydrogels are three-dimensional polymer networks in which individual hydrophilic polymer chains are connected,either by physical association or by chemical bonds.Once stimulated by environmental changes,such as the variation of pH or temperature,hydrogels will respond intelligently and achieve a new equilibrium state in a short time,so they have a wide application in pharmaceutical domain as ideal carriers for drug controlled release.This paper introduced different types of controlled release systems and their major influencing factors,reviewed the development and application of mathematical models describing the drug release processes,comparatively analyzed empirical/semi-empirical models and mechanism models,and presented development trends. |
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| Keywords: | hydrogels drug controlled release stimuli-responsivity mathematical model |
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