| 添加氧载体促进林可霉素发酵过程的研究 |
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| 引用本文： | 孟娜,薛正莲,魏胜华,王卫军,吴丁柱.添加氧载体促进林可霉素发酵过程的研究[J].应用化工,2013(12):2198-2200,2203. |
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| 作者姓名： | 孟娜 薛正莲 魏胜华 王卫军 吴丁柱 |
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| 作者单位： | [1]安徽工程大学生物与化学工程学院,安徽芜湖241000 [2]微生物发酵安徽省工程技术研究中心,安徽芜湖241000 |
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| 基金项目： | 安徽省教育厅自然科学基金项目资助（KJ20108015） |
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| 摘 要： | 为了有效的改善林可霉素发酵液中的氧传递速率,研究了氧载体对林可霉素发酵的影响。结果表明,正十二烷作为氧载体的效果较好,能有效提高林肯链霉菌发酵合成林可霉素的能力。在发酵开始的第24 h添加4%的正十二烷,在摇瓶和发酵罐中发酵,可以分别提高林可霉素的效价26.3%和28.8%。
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| 关 键 词： | 林可霉素 氧载体 林肯链霉菌 发酵 |
Enhanced lincomycin fermentation by addition of oxygen-vectors |
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| MENG Na,XUE Zheng-lian,WEI Sheng-hua,WANG Wei-jun,WU Ding-zhu.Enhanced lincomycin fermentation by addition of oxygen-vectors[J].Applied chemical industry,2013(12):2198-2200,2203. |
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| Authors: | MENG Na XUE Zheng-lian WEI Sheng-hua WANG Wei-jun WU Ding-zhu |
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| Affiliation: | 1 (I. College of Biological and Chemical Engineering, Anhui Polytechnic University, Wuhu 241000 ,China; 2. Anhui Engineering Technology Research Center of Microbial Fermentation ,Wuhu 241000 ,China) |
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| Abstract: | In order to effectively improve the oxygen transfer rate in lincomycin fermentation. The effect of oxygen-vectors on fermentation was studied. The results showed that n-dodecane was the most effective to the process, could promote the ability of Streptomyces lincolnensis to product lincomycin. The lincomycin production can be improved to 26.3% and 28.8% respectively by adding 4% n-dodecane at the begin ning of 24 h ferment in shake flask and fcrmentor. |
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| Keywords: | lincomycin oxygen-vector Streptomyces lincolnensis fermentation |
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