| 离子液体中二步法合成钙拮抗剂尼群地平 |
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| 引用本文： | 伍小云. 离子液体中二步法合成钙拮抗剂尼群地平[J]. 化工时刊, 2008, 22(12): 14-16 |
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| 作者姓名： | 伍小云 |
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| 作者单位： | 南方医科大学药学院,广东,广州,510515 |
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| 基金项目： | 广东省医药卫生科研项目 |
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| 摘 要： | 以间硝基苯甲醛、乙酰乙酸甲酯及合成的3-氨基-2-丁烯酸乙酯和间硝基苯甲醛、乙酰乙酸乙酯及3-氨基-2-丁烯酸甲酯在离子液体1-丁基吡啶四氟硼酸盐中环合合成第二代1,4-二氢吡啶类钙拮抗剂尼群地平,收率分别为93%和94%,离子液体回收套用至少3次,产物收率没有明显降低。
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| 关 键 词： | 1 4-二氢吡啶类钙拮抗剂 尼群地平 离子液体 |
Synthesis of Calcium Antagonist Nitrendipine in Ionic Liquid |
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| Wu Xiaoyun. Synthesis of Calcium Antagonist Nitrendipine in Ionic Liquid[J]. Chemical Industry Times, 2008, 22(12): 14-16 |
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| Authors: | Wu Xiaoyun |
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| Affiliation: | Wu Xiaoyun (School of Pharmaceutical Sciences, Southern Medical University, Guangdong Guangzhou 510515 ) |
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| Abstract: | The second generation 1,4-dihydropyridine calcium antagonist Nitrendipine was synthesized through the condensation of 3-nitrobenzaldehyde,methyl acetoacetate and ethyl 3-aminocrotonate,or the condensation of 3-nitrobenzaldehyde,methyl acetoacetate and ethyl 3-aminocrotonate in an ionic liquid,n-butyl pyridinium tetrafluoroborate at 100-110℃ for 3 h in yield of 93% and 94%.The ionic liquid can be recycled in yield of 90%,and can be reused at least 3 times without loss in activity. |
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| Keywords: | 1 4-dihydropyridine calcium antagonist nitrendipine synthesis ionic liquid |
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