时间温度指示剂研究进展

时间温度指示剂（TTI）是一种用于实时监测食品、药物等产品安全性的新型指示剂，它通过发生物理或化学变化来产生时间温度累积效应从而用来记录产品的温度变化历程并指示产品剩余货架信息，解决了传统标定保质期的做法所带来的不能实时监测产品质量的问题。本文从分析时间温度指示剂在实际生活中的重要意义出发，阐述了时间温度指示剂的分类，从指示原理上主要分为扩散型、聚合反应型和酶反应型；不同类型指示剂的工作原理分别为：扩散型指示剂主要是通过熔融物质的流动来进行实时指示，聚合反应型是通过碳碳三键的聚合反应和分子构象转变引起的颜色变化来起到时间温度的指示作用，酶反应型指示剂是通过淀粉与酶的显色反应来进行时间温度指示；制备方法主要分为物理法、化学法以及物理化学法；还介绍了时间温度指示剂在应用中的选择。

Progress of time-temperature indicators

Time-temperature indicator (TTI) is a novel means to monitor the security of some host products such as food and vaccines，which can record the course and reflect the remaining shelf life of these host products by time-temperature accumulative effects of physical and chemical change，thus solving the problem of shelf life is not a real-time monitoring indicator of host product quality. The latest advances in TTIs were reviewed；their kinds，working principles，preparations and applications were expounded. Kinds of TTIs were divided into diffuse type，polymerization reaction type and enzyme reaction type by their indicating principle. The diffusion-type indicator is carried by the flow of molten material directions，polymerization type is for the carbon-carbon triple bond polymerization reaction and the molecular conformation change induced color change to play the time-temperature indicator effects，enzyme reaction type indicator is through the starch with enzyme color reaction to time temperature indicator. Preparation methods are divided into physical，chemical and physical chemical method. Applications choice is also discussed.