In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds |
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| Affiliation: | 1. Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China;2. School of Materials Science and Engineering, Hubei University of Technology, Wuhan 430068, China;3. Department of Physics, Wuhan University, Wuhan 430072, China;4. Hubei Provincial Key Laboratory of Green Materials for Light Industry, Hubei University of Technology, Wuhan 430068, China;1. School of Electrical & Electronic Engineering, Shangqiu Normal University, Shangqiu, 476000, Henan, People''s Republic of China;2. College of Science, Tianjin Polytechnic University, 300387, Tianjin, People''s Republic of China;1. School of Environment, Tsinghua University, Beijing 100084, China;2. Key Laboratory for Solid Waste Management and Environment Safety, Ministry of Education of China, Beijing 100084, China;3. College of Architecture and Civil Engineering, Wenzhou University, Wenzhou 325035, China;4. School of Materials Science and Engineering, Southeast University, Nanjing 211189, China;1. Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND 58102, USA;2. Department of Civil and Environmental Engineering, North Dakota State University, Fargo, ND 58102, USA;3. Center of Excellence on Hazardous Substance Management, Chulalongkorn University, Bangkok 10330, Thailand;4. International Postgraduate Programs in Environmental Management, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand |
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| Abstract: | In this study, cadmium selenide/zinc sulfide (CdSe/ZnS) quantum dots (QDs) were introduced into poly(lactic acid) (PLA) for fabrication of photoluminescent PLA/QDs scaffolds. TEM images revealed that the QDs were uniformly dispersed in the PLA. Compressive modulus and thermal stability of the PLA/QDs scaffolds are higher than those of the unfilled PLA scaffold. Cytotoxicity test results confirmed the non-cytotoxicity of the PLA/QDs scaffolds. During the process of in vitro degradation, the degradation rate of the PLA was accelerated by the presence of the QDs, and the molecular weight distributions of the PLA/QDs scaffolds were much broader when compared with the unfilled PLA ones. During the first 84 weeks of the degradation process, the photoluminescence (PL) intensity of the PLA/QDs scaffolds decreased with almost the same degradation ratio. The results suggested that the CdSe/ZnS QDs have potential applications for monitoring in vivo degradation of tissue engineering scaffolds. |
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| Keywords: | A. Polymer–matrix composites (PMCs) A. Nano-structures B. Optical properties/techniques In vitro degradation |
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