An efficient protocol for copper- and amine-free Sonogashira reactions catalyzed by mononuclear palladacycle complexes containing bidentate phosphine ligands |
| |
| Affiliation: | 1. Coordination Chemistry Research Lab, Department of Chemistry, Government Science College, Jabalpur (M.P.) 482001, India;2. Instituto de Quimica Rosario Area Inorganica Facultad de Cs. Bioquimicas y Farmaceuticas Universidad Nacional de Rosario Suipacha 531 S2002LRK Rosario, Argentina;1. Department of Chemistry, National Institute of Technology Rourkela, Odisha, 769008, India;2. Schools of Basic Science, Indian Institute of Technology Indore, MP, 452017, India |
| |
| Abstract: | An efficient protocol for copper- and amine-free Sonogashira coupling of aryl halides with phenylacetylene in mild reaction conditions under air is reported using moisture/air-stable and robust palladacycle phosphine complexes as catalyst precursors. The use of 0.001 mol% catalysts in the presence of Cs2CO3 allows the coupling reaction to proceed with moderate to good yields. Also, 31P NMR studies showed that palladacycle 1 can be reduced to zerovalent palladium in methanol, by forming dppe dioxide. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
