Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli |
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| Authors: | Yu Hang Leung Alan M. C. Ng Xiaoying Xu Zhiyong Shen Lee A. Gethings Mabel Ting Wong Charis M. N. Chan Mu Yao Guo Yip Hang Ng Aleksandra B. Djurišić Patrick K. H. Lee Wai Kin Chan Li Hong Yu David Lee Phillips Angel P. Y. Ma Frederick C. C. Leung |
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| Affiliation: | 1. Department of Physics, University of Hong Kong, , Hong Kong;2. Nanostructure Institute for Energy and Environmental Research, Division of Physical Sciences, South University of Science and Technology of China, , Shenzhen, China;3. School of Energy and Environment, City University of Hong Kong, , Kowloon Tong, Hong Kong;4. Pharmaceutical and Life Sciences Division, Waters Corporation, , Manchester, UK;5. School of Biological Sciences, University of Hong Kong, , Hong Kong;6. Department of Chemistry, University of Hong Kong, , Hong Kong |
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| Abstract: | The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally‐friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation. |
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| Keywords: | antibacterial activity MgO nanoparticles proteomics toxicity |
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