Magneto‐Plasmonic Au‐Fe Alloy Nanoparticles Designed for Multimodal SERS‐MRI‐CT Imaging |
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Authors: | Vincenzo Amendola Stefano Scaramuzza Lucio Litti Moreno Meneghetti Gaia Zuccolotto Antonio Rosato Elena Nicolato Pasquina Marzola Giulio Fracasso Cristina Anselmi Marcella Pinto Marco Colombatti |
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Affiliation: | 1. Department of Chemical Sciences, University of Padova, , Padova, Italy;2. Department of Oncology and Surgical Sciences, University of Padova, , Padova, Italy;3. Dept. of Neurological and Movement Sciences, University of Verona, , Verona, Italy;4. Department of Computer Sciences, University of Verona, , Verona, Italy;5. Department of Pathology and Diagnostics, University of Verona, , Verona, Italy |
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Abstract: | Diagnostic approaches based on multimodal imaging are needed for accurate selection of the therapeutic regimens in several diseases, although the dose of administered contrast drugs must be reduced to minimize side effects. Therefore, large efforts are deployed in the development of multimodal contrast agents (MCAs) that permit the complementary visualization of the same diseased area with different sensitivity and different spatial resolution by applying multiple diagnostic techniques. Ideally, MCAs should also allow imaging of diseased tissues with high spatial resolution during surgical interventions. Here a new system based on multifunctional Au‐Fe alloy nanoparticles designed to satisfy the main requirements of an ideal MCA is reported and their biocompatibility and imaging capability are described. The MCAs show easy and versatile surface conjugation with thiolated molecules, magnetic resonance imaging (MRI) and computed X‐ray tomography (CT) signals for anatomical and physiological information (i.e., diagnostic and prognostic imaging), large Raman signals amplified by surface enhanced Raman scattering (SERS) for high sensitivity and high resolution intrasurgical imaging, biocompatibility, exploitability for in vivo use and capability of selective accumulation in tumors by enhanced permeability and retention effect. Taken together, these results show that Au‐Fe nanoalloys are excellent candidates as multimodal MRI‐CT‐SERS imaging agents. |
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Keywords: | nanoparticles bioimaging SERS MRI CT |
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