Gadolinium‐Conjugated Gold Nanoshells for Multimodal Diagnostic Imaging and Photothermal Cancer Therapy |
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| Authors: | Andrew J Coughlin Jeyarama S Ananta Nanfu Deng Irina V Larina Paolo Decuzzi Jennifer L West |
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| Affiliation: | 1. Department of Bioengineering, Rice University, , Houston, TX, 77005 USA;2. Department of Translational Imaging, The Methodist Hospital Research Institute, , Houston, TX, 77030 USA;3. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, , Houston, Texas, 77030 USA;4. Department of Biomedical Engineering, Duke University, , Durham, NC, 27708 USA |
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| Abstract: | Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium‐conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X‐ray, optical coherence tomography, reflectance confocal microscopy, and two‐photon luminescence. Additionally, these particles effectively convert near‐infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium‐nanoshells for image‐guided photothermal ablation. |
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| Keywords: | gold‐silica nanoshells magnetic resonance imaging X‐ray imaging optical imaging photothermal ablation |
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