Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading,Sustained Release,and Cellular Delivery of Therapeutical Proteins |
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| Authors: | Jun Zhang Surajit Karmakar Meihua Yu Neena Mitter Jin Zou Chengzhong Yu |
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| Affiliation: | 1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, , Brisbane, QLD 4072 Australia;2. Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, , Brisbane, QLD 4072 Australia;3. Materials Engineering and Centre for Microscopy and Microanalysis, The University of Queensland, , Brisbane, QLD, 4072 Australia |
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| Abstract: | A rationally designed two‐step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano‐carriers for cellular delivery applications of therapeutical biomolecules. |
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| Keywords: | silica vesicles entrance sizes cellular delivery sustained release therapeutic proteins |
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