Percutaneous penetration of hexachlorophene as related to receptor solutions. |
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| Authors: | D W Brown A G Ulsamer |
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| Affiliation: | 1. Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 157 84, Greece;2. Department of Clinical Therapeutics, School of Medicine, Alexandra General Hospital, National and Kapodistrian University of Athens, Athens, 115 28, Greece;3. Hematology Laboratory–Blood Bank, Aretaieio Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 28, Athens, Greece;4. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 115 27, Athens, Greece;5. Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 157 01, Greece;6. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, 115 27, Greece |
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| Abstract: | The in vitro penetration of hexachlorophene (HCP) through the stratum corneum was investigated in relation to the receptor solution. Diffusion studies with human stratum corneum showed that 1.0% HCP in propylene glycol achieved a significantly greater (P < 0.025) mean maximum steady rate of penetration (over 1–24 hr) when normal saline was replaced by 0.2 m-phosphate buffer as the receptor solution. The varying degree of solubility of HCP in the reference solutions studied supports the penetration data. Under the experimental conditions used, HCP was not metabolized as it traversed the stratum corneum. |
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