Basophilic blast crisis in chronic myeloid leukemia |
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Authors: | JR García Fernández MA montalbán ML Martín MC Ortiz MA Martínez A García Marcilla |
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Affiliation: | Division of Pediatrics, Rambam Medical Center and Technion, Faculty of Medicine, Haifa, Israel. |
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Abstract: | Acute nonoliguric renal failure developed in a 13-year-old girl, 1 month after the institution of isoniazid therapy because of a positive tuberculin test at school screening. A renal biopsy demonstrated severe crescentic glomerulonephritis with focal interstitial changes. Discontinuation of isoniazid and a short course of steroids and cyclophosphamide therapy were followed by complete recovery. Whereas isoniazid has been shown to induce a lupus-like syndrome and antihistone antinuclear antibodies, our patient displayed none of the clinical or immunological features that are characteristic of drug-induced lupus. Furthermore, none of the identifiable causes for crescentic glomerulonephritis was evident in this girl. To the best of our knowledge this is the first report suggesting a possible association of crescentic glomerulonephritis to isoniazid treatment. |
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