超声波在干细胞治疗中的应用进展

超声波是指频率在 20 kHz 以上的机械波，具有机械效应、热效应和空化效应。不同强度的超声波作用于生物体，会对其器官、组织和细胞等产生不同程度的生物学效应。随着工程技术的发展，超声波已在医学显像、实体肿瘤治疗等生物医学领域具有广泛应用，低强度超声波也成为辅助干细胞治疗各类疾病的重要工程手段。深入了解超声波在干细胞治疗中所起的作用及机制，将促进广大研究者对超声波技术的了解，从而重视并加大超声波在该领域的研究力度及广泛应用。该文综述了超声波在干细胞治疗中的研究进展，对超声促进干细胞增殖、分化和迁移、细胞示踪显影及靶向药物传递等前沿研究进展进行了全面介绍，并对超声波在干细胞治疗领域的应用前景提出了设想。

The Application Progress of Ultrasound Technology for Stem Cell Therapy

Ultrasound is a mechanical vibration wave with frequencies above 20 kHz, which has mechanical effect, heating effect and cavitations effect. The ultrasound with different intensity has been applied fororganisms tissues and cells with different biological effects. With the development of engineering technology, ultrasound has been widely applied to medical imaging, solid tumor treatment and other directions in biomedicine. Low intensity ultrasound has gradually been considered as an important engineering tool to assist the stem cell therapy of various diseases. The detailed understanding of ultrasound for stem cell therapy will promote further application of ultrasonic technology and the development of clinic applications. The progress of ultrasound for stem cell therapy is introduced in this review, including promoting stem cell proliferation,differentiation and migration, tracking stem cell by ultrasound image and target drug delivery. Finally, ideas about improving ultrasound for stem cell therapy in future are discussed.