| 通过式净化-液相色谱-串联质谱快速筛查水产品中15类107种兽药多残留的方法研究 |
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| 引用本文： | 孙晓杰,高金芳,李兆新,郭萌萌,邢丽红,孙伟红,翟毓秀. 通过式净化-液相色谱-串联质谱快速筛查水产品中15类107种兽药多残留的方法研究[J]. 食品安全质量检测学报, 2020, 11(22): 8240-8246 |
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| 作者姓名： | 孙晓杰 高金芳 李兆新 郭萌萌 邢丽红 孙伟红 翟毓秀 |
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| 作者单位： | 1.农业部水产品质量安全检测与评价重点实验室,1.农业部水产品质量安全检测与评价重点实验室,1.农业部水产品质量安全检测与评价重点实验室,1.农业部水产品质量安全检测与评价重点实验室,1.农业部水产品质量安全检测与评价重点实验室,1.农业部水产品质量安全检测与评价重点实验室,1.农业部水产品质量安全检测与评价重点实验室 |
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| 基金项目： | 山东省农业重大应用技术创新项目(SF1405303301)、中国水产科学研究院基本科研业务费项目(2020TD71)、中国水产科学研究院黄海水产研究所基本科研业务费项目(20603022019001) |
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| 摘 要： | 目的 建立水产品基质中15类包含107种药物多残留的快速筛查方法。方法 通过多溶剂分步提取-通过式净化, 结合液相色谱-串联质谱仪, 在MRM模式下正、负离子同时扫描监测水产品, 实现水产品中15类107种药物多残留的快速筛查, 并用于实际水产样品中药物残留含量的测定。结果 所有药物在35 min内分离良好, 方法线性范围为0.1~200 ng/mL, 相关系数均大于0.995; 检出限为0.1~5.0 μg/kg (S/N>3), 定量限为0.3~10 μg/kg (S/N>10); 回收率为40.0%~120%, 相对标准偏差均小于15%。结论 方法的准确性和灵敏度较高, 重现性好, 适合水产基质中药物多残留的高通量、快速筛查, 能够满足国家限量法规的要求。
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| 关 键 词： | 水产品 兽药 多残留 快速筛查 液相色谱-串联质谱 |
| 收稿时间： | 2020-10-09 |
| 修稿时间： | 2020-11-10 |
Simultaneous determination of 15 categories and 107 kinds of veterinary drugs in aquatic products by pass-through purification and liquid chromatography-tandem mass spectrometry |
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| SUN Xiao-Jie,GAO Jin-Fang,LI Zhao-Xin,GUO Meng-Meng,XING Li-Hong,SUN Wei-Hong,ZHAI Yu-Xiu. Simultaneous determination of 15 categories and 107 kinds of veterinary drugs in aquatic products by pass-through purification and liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2020, 11(22): 8240-8246 |
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| Authors: | SUN Xiao-Jie GAO Jin-Fang LI Zhao-Xin GUO Meng-Meng XING Li-Hong SUN Wei-Hong ZHAI Yu-Xiu |
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| Affiliation: | 1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences |
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| Abstract: | |
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| Keywords: | aquatic products veterinary drugs multi-residue rapid screening LC-MS/MS |
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