Application of immobilized lipase in production of camptosar (CPT-11) |
| |
Authors: | John C Sih |
| |
Affiliation: | (1) Chemical Process Research and Development, Pharmacia and Upjohn Company, 49001 Kalamazoo, Michigan |
| |
Abstract: | Lipase fromPseudomonas cepaica (Amano, PS-30) was immobilized on celite and used in organic solvent for the selective acylation of a key alcohol intermediate.
The compound was transformed in the synthesis to the anticancer drug Camptosar (CPT-11). Catalyst activity was influenced
by the water content and method used to dry the catalyst. This resolution has been conducted on production scale with equal
weight of recyclable catalyst. |
| |
Keywords: | Anticancer drug Camptosar immobilized PS-30 lipase selective acylation |
本文献已被 SpringerLink 等数据库收录! |