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Measurement of local gas holdup in bubble columns via a non-isokinetic withdrawal method |
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| Authors: | Sergio García-Salas Carlos Orozco-Alvarez R Michael Porter Frederic Thalasso |
| Affiliation: | aDepartment of Biotechnology and Bioengineering, Centro de Investigación y de Estudios Avanzados del IPN, Apdo. Postal 14-740, México D. F. 07360, Mexico bDepartment of Bioengineering, Unidad Profesional Interdisciplinaria de Biotecnología del IPN. México. Av. Acueducto S/N, Ticomán, México D. F. 07340, Mexico cDepartment of Mathematics, Centro de Investigación y de Estudios Avanzados del IPN, Apdo. Postal 14-740, México D. F. 07360, Mexico |
| Abstract: | An inexpensive method was developed to measure local gas holdup based on withdrawal of the air–liquid dispersion in bioreactors under non-isokinetic conditions. The method was tested with several suction probe designs and withdrawal pressures using coalescing and non-coalescing model media as well as during yeast fermentations. Simultaneously, gas holdup was measured manometrically. With a straight end probe and vacuum pressure of 3 kPa, local gas holdup measurements presented a relative error <6% compared to the manometric method, independently of the media composition. This method was used to characterize local gas holdup in a bubble column. Two new parameters are proposed to characterize non-gassed volume and gas holdup homogeneity. |
| Keywords: | Bioreactor Bubble column Fermentation Hydrodynamics Coalescing Non-coalescing media |
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