叶酸辅酶模型化合物的比较

对一类叶酸辅酶模型化合物－－不对称取代咪唑啉盐的结构从理论上进行了比较研究，分析了模型化合物的反应活性与电子结构的关系，发现该类模型转移一碳单元的行为与被转移碳原子所连的两个氮原子的性质密切相关。随着模型化合物中苯磺酰基对位上取代基给电子能力的增加，咪唑啉五元环上两个氮原子的性质逐渐接近，它们的差别越来越小，模型转移一碳单元的反应活性也逐渐增加。

Comparative study of folate cofactor models

The structure of a type of tetrahydrofolate cofactor model,asymmetric substitute imidazolinium,is studied theoretically and the relation between the compound's reactivity and its electronic structure is analyzed.It has been found that the transfer of one-carbon unit of this type of tetrahydrofolate cofactor models is closely related to the properties of the two nitrogen atoms linking to the transferred carbon atom.It has also been found that the properties of N3 and N6 become more and more similar and the model becomes more and more active to transfer one-carbon unit with the changing of the group on the para -position of benzenesulfonyl from an electronic acceptor to a donor.