| 光/温度双重响应性两亲嵌段共聚物PEO-b-P(NIPAM-co-NBA)的制备及其光控释药性能研究 |
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| 引用本文： | 张然然,姚日生. 光/温度双重响应性两亲嵌段共聚物PEO-b-P(NIPAM-co-NBA)的制备及其光控释药性能研究[J]. 安徽化工, 2014, 0(6): 16-20 |
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| 作者姓名： | 张然然 姚日生 |
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| 作者单位： | 1. 合肥工业大学医学工程学院，安徽合肥 230009; 合肥工业大学化学工程学院，安徽合肥 230009
2. 合肥工业大学医学工程学院,安徽合肥,230009 |
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| 摘 要： | 通过可逆加成-断裂链转移聚合(RAFT)的方法合成具有光敏和温敏性的两亲嵌段共聚物PEO-b-P(NIPAM-co-NBA),使用核磁氢谱手段表征两亲嵌段共聚物具有紫外光响应性,同时以尼罗红为药物模型分子考查光敏含量对胶束释放性能的影响,证实了光敏单元含量少的聚合物胶束溶液中尼罗红的释放速率最快。
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| 关 键 词： | 两亲嵌段共聚物 可逆加成-断裂链转移聚合 光响应 温度响应 尼罗红 |
Study on UV Responsive Performance of PEO-b-P(NIPAM-co-NBA) Diblock Copolymers as the Light-and Thermo-Responsive Materials |
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| ZHANG Ran-ran,YAO Ri-sheng. Study on UV Responsive Performance of PEO-b-P(NIPAM-co-NBA) Diblock Copolymers as the Light-and Thermo-Responsive Materials[J]. Anhui Chemical Industry, 2014, 0(6): 16-20 |
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| Authors: | ZHANG Ran-ran YAO Ri-sheng |
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| Affiliation: | ZHANG Ran-ran;YAO Ri-sheng;School of Medical Engineering,Hefei University of Technology;School of Chemical Engineering,Hefei University of Technology; |
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| Abstract: | In this work, we synthesized PEO-b-P（NIPAM-co-NBA） diblock copolymers as the light-and thermo-responsive materials by reversible addition fragment chain transfer （RAFT） polymerization. To verify the UV light induced photocleavage reactions of the o-NB esters in this work, the 1H NMR measurement was preformed. And then, using Nile Red as the model drug, we investigated the influence of the NBA content on drug release behavior of the micelles self-assembled by the light-and thermo-responsive block polymer. The results indicated that the less the o-NB moieties the polymer has, the faster the NR released. |
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| Keywords: | amphiphilic block copolymer reversible addition fragment chain transfer polymerization photo-responsive thermo-responsive Nile Red |
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