Graphical representation of the salient conformational features of protein residues |
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Authors: | Pal Debnath; Chakrabarti Pinak |
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Affiliation: | Department of Biochemistry, Bose Institute, P-1/12 CIT Scheme VIIM, Calcutta 700 054, India |
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Abstract: | A composite plot for depicting in two dimensions the conformationand the secondary structural features of protein residues hasbeen developed. Instead of presenting the exact values of themain- and side-chain torsion angles ( , and 1), it indicatesthe region in the three-dimensional conformational space towhich a residue belongs. Other structural aspects, like thepresence of a cis peptide bond and disulfide linkages, are alsodisplayed. The plot may be used to recognize patterns in thebackbone and side-chain conformation along a polypeptide chainand to compare protein structures derived from X-ray crystallography,NMR spectroscopy or molecular modelling studies and also tohighlight the effect of mutation on structure. |
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Keywords: | conformation/ protein engineering/ protein structural comparison/ secondary structure/ structural plot |
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