Study on a piezoelectric micropump for the controlled drug delivery system |
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Authors: | Qifeng Cui Chengliang Liu Xuan F Zha |
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Affiliation: | (1) School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai, 200240, China;(2) National Institute of Standards and Technology, University of Maryland, Gaithersburg, MD 20899, USA |
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Abstract: | We present the design of a new controlled drug delivery system potential for in vitro injection of diabetics. The system incorporates
some integrated circuit units and microelectromechanical system devices, such as micropump, microneedle array and microsensor.
Its goal is to achieve safer and more effective drug delivery. Moreover, a valveless micropump excited by the piezoelectric
actuator is designed for the drug delivery system, and a simple fabrication process is proposed. A dynamic model is developed
for the valveless micropump based upon the mass conservation. To characterize the micropump, a complete electro-solid-fluid
coupling model, including the diffuser/nozzle element and the piezoelectric actuator, is built using the ANSYS software. The
simulation results show that the performance of micropump is in direct proportion to the stroke volume of the pump membrane
and there is an optimal thickness of the piezoelectric membrane under the 500 V/mm electric field. Based on this simulation
model, the effects of several important parameters such as excitation voltage, excitation frequency, pump membrane dimension,
piezoelectric membrane dimension and mechanical properties on the characteristics of valveless micropump have been investigated. |
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Keywords: | Drug delivery system Valveless micropump Simulation Piezoelectric actuator Optimization |
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