Semiautomated enzyme immunoassay of thyrotropin as a mass screening test for neonatal hypothyroidism |
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| Authors: | K Miyai T Tsuruhara S Kusuda K Ishibashi M Kawashima H Mizuta O Nose H Yabuuchi T Oura |
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| Affiliation: | Department of Laboratory Medicine and Central Laboratory for Clinical Investigation, Osaka University Medical School, Osaka City, Japan. |
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| Abstract: | A sensitive, simple, and rapid semiautomated sandwich enzyme immunoassay (EIA) was developed for measuring thyrotropin in dried blood samples on filter paper for use in screening for neonatal hypothyroidism. Good correlation was found between values for thyrotropin determined by this method and those determined by radioimmunoassay (RIA) (r=0.94). In pilot tests on 17,160 newborn infants in the general population, five cases of primary hypothyroidism were detected by both EIA and RIA. The recall rate was slightly highter in EIA than in RIA. |
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