| Thermosensitive Poly(N-isopropylacrylamide-co-acrylonitrile) Hydrogels with Rapid Response |
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| 作者姓名： | 黄健 黄志明 包永忠 翁志学 |
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| 作者单位： | State Key Laboratory of Polymer Reaction Engineering, Zhejiang University, Hangzhou 310027, China |
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| 摘 要： | Acrylonitrile （AN） was copolymerized with N-isopropylacrylamide （NIPA） to synthesize thermosensitive hydrogels, and the on-off switch behavior of poly（NIPA-co-AN） hydrogels with different fraction of hydrophobic component （AN） was investigated. It is found that the lower critical solution temperature （LCST）, the swelling ratio at certain temperature and the reswelling rate of poly（NIPA-co-AN） hydrogels decreased as AN unit fraction in copolymers increased. In order to improve the responsive rate of poly（NIPA-co-AN） hydrogels, they were further treated by surface crosslinking using N, N′-methylene bisacrylamide （BIS） as a crosslinking agent. The swelling and deswelling behaviors of these copolymers were compared with those of the untreated hydrogels. The results indicated that the responsive rate of poly（NIPA-co-AN） hydrogel was improved by surface crosslinking. The resulting hydrogels bearing cyano groups with fast response have potential applications in the field of drug-controlled release and immobilization of biomolecules.
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| 关 键 词： | 非离子型凝胶球 溶胀行为 聚合反应 快速响应 聚（异丙基丙烯酰胺-丙烯腈）水凝胶 |
| 收稿时间： | 2005-04-19 |
| 修稿时间： | 2005-04-192005-09-02 |
Thermosensitive Poly(N-isopropylacrylamide-co-acrylonitrile) Hydrogels with Rapid Response |
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| Jian HUANG, Zhiming HUANG, Yongzhong BAO,Zhixue WENG.Thermosensitive Poly(N-isopropylacrylamide-co-acrylonitrile) Hydrogels with Rapid Response[J].Chinese Journal of Chemical Engineering,2006,14(1):87-92. |
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| Authors: | Jian HUANG Zhiming HUANG Yongzhong BAO Zhixue WENG |
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| Affiliation: | State Key Laboratory of Polymer Reaction Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | Acrylonitrile (AN) was copolymerized with N-isopropylacrylamide (NIPA) to synthesize thermosensitive bydrogels, and the on-off switch behavior of poly(NIPA-co-AN) hydrogels with different fraction of hydrophobic component (AN) was investigated. It is found that the lower critical solution temperature (LCST), the swelling ratio at certain temperature and the reswelling rate of poly(NIPA-co-AN) hydrogels decreased as AN unit fraction in copolymers increased. In order to improve the responsive rate of poly(NIPA-co-AN) hydrogels, they were further treated by surface crosslinking using N, N'-methylene bisacrylamide (BIS) as a crosslinking agent. The swelling and deswelling behaviors of these copolymers were compared with those of the untreated hydrogels. The results indicated that the responsive rate of poly(NIPA-co-AN) hydrogel was improved by surface crosslinking. The resulting hydrogels bearing cyano groups with fast response have potential applications in the field of drug-controlled release and immobilization of biomolecules. |
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| Keywords: | polymerization hydrogel rapid response |
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