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P450(BM3) on steroids: the Swiss Army knife P450 enzyme just gets better
Authors:Wong Luet-Lok
Affiliation:Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, Oxford OX1 3QR, UK. luet.wong@chem.ox.ac.uk
Abstract:The catalytic regio- and stereoselective oxidation of aliphatic C-H bonds by using atmospheric dioxygen as the oxidant is a highly desirable reaction. Reetz and co-workers have recently reported the development of P450(BM3) mutants that oxidise testosterone with greatly increased turnover activity, total stereoselectivity and >95?% regioselectivity.
Keywords:directed evolution  heme enzymes  oxidation  P450 monooxygenases  steroids
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