| 微/纳米结构含锌硅酸钙基涂层成骨性能研究 |
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| 引用本文： | 张昕玮,胡丹丹,李恺,谢有桃,黄利平,郑学斌.微/纳米结构含锌硅酸钙基涂层成骨性能研究[J].热喷涂技术,2022,14(1):8-18. |
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| 作者姓名： | 张昕玮 胡丹丹 李恺 谢有桃 黄利平 郑学斌 |
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| 作者单位： | 中国科学院上海硅酸盐研究所 |
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| 基金项目： | 国家自然科学基金面上项目(No.51971236)； |
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| 摘 要： | 骨科植入物涂层的表面形貌和化学组成对炎症反应的进程和骨形成的发生都发挥着重要调节作用。为综合利用微/纳米仿生结构和生物活性元素的优势，将含锌(Zn)的纳米结构物质引入到经水热处理后的等离子喷涂硅酸钙(calcium silicate, CS)涂层表面，对所制备涂层的物相组成、表面和截面形貌、比表面积、Zeta电位和生理环境下离子溶出等物理化学性能进行了表征。相比于常规CS涂层，具有微/纳米复合结构的CS和含锌CS涂层拥有更高比表面积和孔容，可吸附更多血清蛋白和纤维连接蛋白，通过刺激细胞内整合素以及下游vinculin和FAK基因表达，提高了骨髓间充质干细胞(BMSCs)铺展能力。涂层中锌的引入进一步提高了其表面BMSCs的增殖能力和与成骨细胞分化相关的基因表达。具有微/纳米复合结构的涂层明显上调了RAW264.7巨噬细胞中M2表型因子(CD206和ARG)基因表达，而涂层中溶出的Zn2+显著提高了RAW264.7细胞中抑炎症因子(IL-1ra和IL-10)基因表达，促使其向抑炎症表型转化。骨科植入物涂层表面锌元素和纳米结构的引入有利于创建良好的骨免疫微环境，促进骨...
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| 关 键 词： | 硅酸钙涂层 纳米结构 锌 骨形成 炎症反应 |
A Study on Osteogenic Properties of Micro/nanostructured Zinc-containing Calcium Silicate-based Coatings |
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| Zhang Xiwei,Hu Dandan,Li Kai,Xie Youtao,Huang Liping,Zheng Xuebin.A Study on Osteogenic Properties of Micro/nanostructured Zinc-containing Calcium Silicate-based Coatings[J].Thermal Spray Technology,2022,14(1):8-18. |
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| Authors: | Zhang Xiwei Hu Dandan Li Kai Xie Youtao Huang Liping Zheng Xuebin |
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| Affiliation: | Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 201899 |
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| Abstract: | The surface morphology and chemical composition of orthopedic implant coatings play an important role in regulating the process of inflammatory response and the occurrence of osteogenesis. In this paper, to take advantage of biomimetic micro/nano-structures and bioactive elements, zinc-containing nanostructures were introduced onto plasma-sprayed calcium silicate (CS) coatings via hydrothermal treatment. The physical and chemical properties of the as-prepared coatings, such as phase composition, surface and cross-sectional morphology, specific surface area, Zeta potential and ion dissolution under physiological environment, were |
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| Keywords: | Calcium silicate coating Nanostructure Zinc Osteogenesis Inflammatory response |
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