Flow-based autocorrelation studies for the detection and investigation of single-particle surface-enhanced resonance Raman spectroscopic events |
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Authors: | Cecchini Michael P Stapountzi Margarita A McComb David W Albrecht Tim Edel Joshua B |
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Affiliation: | Department of Materials, Imperial College London, London, United Kingdom. |
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Abstract: | We report on the characterization and detection of single metallic nanoparticles using a combination of correlation spectroscopy and surface-enhanced resonance Raman spectroscopy (SERRS). Minimizing the number of independent characterization steps is critical to efficiently perform such an analysis. In this article, we improve upon conventional diffusion-limited approaches by implementing a flow-based system with high temporal resolution detection. The benefits of flow over diffusion measurements allow for a higher throughput of detected events resulting in shorter analysis times. The nanoparticles are sized using their rotational diffusion time calculated with a modified autocorrelation function. Experiments are performed using Au nanoparticles labeled with the reporter molecule malachite green isothiocyanate on a custom-built Raman spectrometer. |
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