刺五加提取物抗疲劳作用的研究

目的研究刺五加提取物的抗疲劳作用。方法将雄性BALB／C小鼠按体重随机分为4组：空白对照组和200、400、700mg／kgbw3个刺五加提取物剂量组。在给予受试物15d后测定各组的小鼠负重游泳的持续时间，10min无负重游泳的血乳酸水平（静息值、即刻值、泳后20min值）及肝糖原含量的变化。结果：400mg／kgbw，700mg／kgbw的刺五加提取物能提高肝糖元的储备（p〈0．01）：700mg／kgbw刺五加组游泳时间长于空白对照组（p〈0．05）；700mg／kgbw刺五加组血乳酸降低比值高于对照组（p〈0．01）。

Study on Anti-fatigue Function of Acanthopanax Senticosus Extract

Objective To study the anti-fatigue effect of Acanthopanax senticosus extract. Methods The male mice of BALB/ c were randomly divided into four groups according to their body weight: a solvent control group , Acanthopanax senticosus extract 200, 400 and 700mg/kgbw group. The mice were administered respectively with water and 200 , 400, 700mg/kgbw Acanthopanax senticosus extract. After 15 days, the forced swimming test, blood lactic acid and hepatic glycogen content were determined. Results: The swimming time of mice in 700mg/kg.bw group was significantly prolonged as compared with that in control group (p<0.05) . 400mg/kgbw, 700mg/kgbw groups could obviously increased hepatic glycogen storage (p<0.01). 700mg/kg.bw groups could significantly accelerate lactic acid clearance after mice swimming (p<0.01) .Conclusion: Acanthopanax senticosus extract has an anti-fatigue effect.