Gangliosides in Podocyte Biology and Disease |
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Authors: | Berkan Savas Giuseppe Astarita Massimo Aureli Dil Sahali Mario Ollero |
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Affiliation: | 1.INSERM, IMRB, Univ Paris Est Créteil, F-94010 Créteil, France; (B.S.); (D.S.);2.Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, 20007 Washington, DC, USA;3.Department of Medical Biotechnology and Translational Medicine, University of Milano, Milano Italy, 20090 Segrate (Milano), Italy;4.Service Néphrologie, AP-HP, Hôpital Henri Mondor, F-94010 Créteil, France |
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Abstract: | Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular membranes, in particular of raft microdomains, they exert multiple functions, some of them capital in cell homeostasis. Their presence in cells is tightly regulated by a balanced expression and function of the enzymes responsible for their biosynthesis, ganglioside synthases, and their degradation, glycosidases. The dysregulation of their abundance results in rare and common diseases. In this review, we make a point on the relevance of gangliosides and some of their metabolic precursors, such as ceramides, in the function of podocytes, the main cellular component of the glomerular filtration barrier, as well as their implications in podocytopathies. The results presented in this review suggest the pertinence of clinical lipidomic studies targeting these metabolites. |
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Keywords: | glycosphingolipids ceramide podocytopathies glomerulopathies glomerulus kidney rafts nephrotic syndrome |
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