The lipid composition of human liver microsomes |
| |
| Authors: | Lucy Waskell Donald Koblin Eleanor Canova-Davis |
| |
| Affiliation: | (1) Department of Anesthesia, University of California, 94143 San Francisco, CA;(2) Veterans Administration Medical Center, University of California, 94143 San Francisco, CA |
| |
| Abstract: | The lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been
determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14%
phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid composition of rat liver microsomes.
The fatty acid composition of human liver microsomes is remarkable only for its content of polyunsaturated fatty acids, with
20% of the fatty acids consisting of arachidonic, docosatetraenoic, docosapentaenoic and docosahexaenoic acids. This value
contrasts with 33% in rats and 9% in rabbits. The molar cholesterol/phospholipid ratio in human liver microsomes is 0.069,
similar to the ratio in rat and rabbit microsomes. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
