Current developments in SELDI affinity technology |
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Authors: | Tang Ning Tornatore Pete Weinberger Scot R |
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Affiliation: | Ciphergen Biosystems, 6611 Dumbarton Circle, Fremont, California 94555, USA. |
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Abstract: | The overall history and recent advancements in Surface-Enhanced Laser Desorption/Ionization (SELDI) affinity technology is reviewed. A detailed account of SELDI technology, utilizing Immobilized-Metal Affinity surfaces, pseudo-specific chromatographic surfaces, and biospecific interactive surfaces, is presented with particular emphasis placed upon examination of fundamental characteristics as well as specific applications for each. Finally, a detailed review of the specific use of such affinity surfaces in fundamental aspects of clinical, process, and research proteomics activity is presented. |
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Keywords: | SELDI SEND ProteinChip surface enhanced laser desorption ionization |
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