| 草酸依地普仑的合成 |
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| 引用本文： | 金俊华,杨永林,包存刚,余以兵,葛秀丽,张奎平. 草酸依地普仑的合成[J]. 广州化工, 2011, 39(6): 67-68 |
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| 作者姓名： | 金俊华 杨永林 包存刚 余以兵 葛秀丽 张奎平 |
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| 作者单位： | 江苏恩华赛德药业有限责任公司,江苏徐州,221007 |
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| 摘 要： | 以5-氰基苯酞为起始原料,经亲核加成、水解、手性拆分,环化和成盐等反应制得抗抑郁药草酸依地普仑,以5-氰基苯酞计,总收率为19%.该方法工艺简单,条件温和,收率较高,适合工业化生产.
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| 关 键 词： | 5-氰基苯酞 草酸依地普仑 合成 |
Synthesis of Escitalopram Oxadate |
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| JIN Jun-hua,YANG yong-lin,BAO Cun-gang,YU Yi-bing,GE Xiu-li,ZHANG Kui-ping. Synthesis of Escitalopram Oxadate[J]. GuangZhou Chemical Industry and Technology, 2011, 39(6): 67-68 |
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| Authors: | JIN Jun-hua YANG yong-lin BAO Cun-gang YU Yi-bing GE Xiu-li ZHANG Kui-ping |
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| Affiliation: | (Jiangsu Nhwa-Thad Pharmaceutical Corporation,Jiangsu Xuzhou 221007,China) |
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| Abstract: | 5-cyanophthalide as the starting material,escitalopram oxalate was prepared via several steps including nucleophilic addition,hydrolysis,chiral separation,cyclization and salt formation.A total yield of escitalopram oxalate was 19%.This synthetic process had milder reactive conditions,with simple procedure and high total yield.The route was suitable for industrial production. |
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| Keywords: | 5-cyanophthalide escitalopram oxadate synthesis |
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