Effect of grapefruit juice on clarithromycin pharmacokinetics |
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Authors: | KL Cheng AN Nafziger CA Peloquin GW Amsden |
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Affiliation: | Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326-1394, USA. |
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Abstract: | To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters. |
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