| 6,6-二溴青霉烷砜酸的合成工艺 |
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| 引用本文： | 朱占海.6,6-二溴青霉烷砜酸的合成工艺[J].当代化工,2012(9):932-933. |
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| 作者姓名： | 朱占海 |
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| 作者单位： | 沈阳燃气有限公司, 辽宁 沈阳 110005 |
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| 摘 要： | 以6-APA(6-氨基青霉烷酸)为起始原料,经重氮化、溴化、成盐、氧化反应制得6,6-二溴青霉烷砜酸,重氮化、溴化反应在水相和有机相中进行,反应温度为-5~-10℃,氧化反应在水相进行,反应温度为5~10℃,总收率为78.8%.反应条件较温和,操作简单,易于工业生产生产.
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| 关 键 词： | 6-APA 吸光度 pH 6 6-二溴青霉烷砜酸 |
Synthesis Technology of 6,6-Dibromide Sulbactam |
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| ZHU Zhan-hai.Synthesis Technology of 6,6-Dibromide Sulbactam[J].Contemporary Chemical Industry,2012(9):932-933. |
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| Authors: | ZHU Zhan-hai |
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| Affiliation: | ZHU Zhan-hai(Shenyang Gas Co.,Ltd.,Liaoning Shenyang 110005,China) |
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| Abstract: | 6,6-Dibromide sulbactam was prepared from 6-aminopenicilanic acid(6-APA) by diazotization,bromination,salification,and oxidation,total yield was 78.8%.The diazotization and bromination were carried out in aqueous phase and organic phase at-5~-10 ℃,and the oxidation was carried out in aqueous phase at 5~10 ℃.The technology is easy to realize industrial production because of mild reaction conditions and simple operation. |
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| Keywords: | 6-APA Absorbance pH 6 6-dibromide sulbactam |
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