Covalent attachment of gold nanoparticles to DNA templates |
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Authors: | Stevenson Karen A Muralidharan G Maya Leon Wells Jack C Barhen Jacob Thundat Thomas |
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Affiliation: | Center for Engineering Science Advanced Research, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. |
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Abstract: | Functionalized gold nanoparticles have been covalently bound to internal, modified sites on double-stranded DNA. Gold nanoparticles coated with mercaptosuccinic acid or thioctic acid were bound to amino-modified thymine bases on double-stranded DNA. Visible absorption spectra, gel electrophoresis, and atomic force microscopy were used to analyze the products. Thiol groups were added to one end of the gold/nanoparticle product, which was then attached to a gold surface. This method has the potential to allow controlled placement of particles with subnanometer precision and to allow attachment of the product to fixed contacts for nanodevice fabrication. |
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