1-(3-氨基苯基)-3-(4-氨基苯基)-2-丙烯-1-酮的合成

以对乙酰氨基苯甲醛、间乙酰氨基苯乙酮为原料经两步反应合成具有光敏性能的1 (3 氨基苯基) 3 (4 氨基苯基) 2 丙烯 1 酮。通过优化实验得到最佳的合成工艺条件为:对乙酰氨基苯甲醛、间乙酰氨基苯乙酮在温度为0℃下,以乙醇为溶剂、氢氧化钠为催化剂,进行羟醛缩合反应3h。分离提纯后,加入盐酸溶液在100℃下水解3h,产物经重结晶提纯。总收率达到61 9%,较1998年的文献[6]提高39 3%。并对产物的结构进行了表征。

Synthesis of 1-(3-Aminophenyl)-3-(4-aminophenyl)- 2-propen-1-one

The photosensitive 1-(3-aminophenyl)-3-(4-aminophenyl)-2-propen-1-one(Ⅱ) was prepared using 3-acetylacetanilide and 4-acetamidobenzaldehyde as raw materials through two step reactions.The best process conditions were attained by optimization of experiments as follows.1-(3-Acetaminophenyl)-3-(4-acetaminophenyl)-2-propen-1-one(Ⅰ) was prepared by aldol condensation reaction of 3-acetylacetanilide and 4-acetamidobenzaldehyde in ethyl alcohol with sodium hydroxide as catalyst and continuous stirring for 3 h at 0 ℃.Ⅰ was then hydrolyzed in aqueous HCl for 3 h and the product was purified by recrystallization.Ⅱ was obtained with total yield of 61.9%, which is 39.3% higher than that in the literature reported in 1998.Structure of the product was also characterized.