Azuki bean (Vigna angularis) extract inhibits the development of experimentally induced atopic dermatitis-like skin lesions in NC/Nga mice |
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Authors: | Therese Marie Collantes Mun-Chual Rho Hyoung-Jun KwonBock-Gie Jung Mia Madel AlfajaroDeok-Song Kim Hyun-Jeong KimMyra Hosmillo Jun-Gyu ParkKyu-Yeol Son Sang-Ik ParkMun-Il Kang Su-Jin ParkSeung Woong Lee Woo-Song LeeKyoung-Oh Cho |
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Affiliation: | a Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea b Eco-Friendly Biomaterial Research Center and AI Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongup 580-185, Republic of Korea |
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Abstract: | The present study investigated the effects of azuki bean (Vigna angularis) extract (VAE) on the progress of atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by 1-chloro-2,4-dinitrobenzene. The efficacy of VAE in NC/Nga mice was determined by measuring gross and histological skin lesions, serum IgE levels, eosinophil ratio in peripheral leucocytes, and mRNA expression levels of interleukin (IL)-4, tumour necrosis factor (TNF)-α and interferon (IFN)-γ in splenocytes. Continuous ingestion of VAE inhibited the development of the AD-like skin lesions in a dose-dependent manner. In the VAE-treated mice, the numbers of mast cells in the skin, eosinophil ratio in peripheral leucocytes, relative mRNA expression of inflammatory cytokines in the spleen, and serum IgE levels were significantly reduced. Results suggest that VAE can inhibit the development of AD-like skin lesions in NC/Nga mice by regulating immune mediators and cells, and may be an effective alternative therapy for AD. |
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Keywords: | Atopic dermatitis Azuki bean IgE Inflammatory cytokines Immune cells NC/Nga mice |
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