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Determination of nonylphenol ethoxylate metabolites in vegetables and crops by high performance liquid chromatography-tandem mass spectrometry |
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| Authors: | Yongxin She Jing Wang Yongquan ZhengWeiqiang Cao Rongyan WangFengshou Dong Xingang LiuMingrong Qian Hu ZhangLiqing Wu |
| Affiliation: | a Institute of Quality Standards and Testing Technology for Agri-Products, Chinese Academy of Agricultural Science, 100081 Beijing, China b Institute of Veterinary and Animal Husbandry, Tibetan Academy of Agricultural and Animal Husbandry, 850009 Lhasa, China c Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, 100193 Beijing, China d Chinese Agricultural Products Monitoring Centre, Hangzhou 310012, Zhejiang, China e Huizhou Import and Export Inspection and Quarantine Bureau, 450012 Huizhou, China |
| Abstract: | A method has been developed for the simultaneous determination of the concentration of nonylphenol (4-NP), nonylphenol monoethoxylates (NP1EO) and nonylphenol diethoxylates (NP2EO) in vegetables and crops by liquid chromatography-tandem quadrupole mass spectrometry (HPLC-MS/MS). These target compounds were extracted from vegetable and crop samples with acetonitrile, and then the extracts were cleaned using solid phase extraction with graphitised carbon black tandem primary secondary amine (PSA) cartridges. The MS method enabled highly reliable identification by monitoring the corresponding ammonium adduct [M+NH4]+ in the positive mode for NP1EO and NP2EO, and the deprotonated molecule [M−H]− in the negative mode for 4-NP. Recoveries for the spiked samples ranged from 65% to 118%. The limit of detection (LOD) of 4-NP, NP1EO and NP2EO was 3, 5 and 0.1 μg kg−1, respectively. This method would be useful for the quick and routine detection of the residues of 4-NP, NP1EO and NP2EO in vegetables and crops. |
| Keywords: | Nonylphenol polyethoxylates Metabolites Vegetables Crops LC-MS/MS |
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