Screening for CGG trinucleotide repeat expansion in the fragile X mental retardation 1 gene in schizophrenic patients |
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Authors: | E Jnsson E Bj?rck J Wahlstr?m P Gustavsson G Sedvall |
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Affiliation: | Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden. |
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Abstract: | Patients diagnosed using DSM-III-R criteria as having schizophrenia and other related disorders (n = 128) were assessed for CGG trinucleotide repeat expansion in the fragile X mental retardation 1 (FMR-1) gene. One subject, a woman with schizophreniform disorder, was found to have a premutation of the gene. Her case report is given. The present investigation supports the view that mutation or premutation of the FMR-1 gene is not of importance for the aetiology of the vast majority of schizophrenic patients. |
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