Production, modification and bio-applications of magnetic nanoparticles gestated by magnetotactic bacteria |
| |
Authors: | Jin Xie Kai Chen Xiaoyuan Chen |
| |
Affiliation: | (1) Department of Radiology, Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5484, USA |
| |
Abstract: | Magnetotactic bacteria (MTB) were first discovered by Richard P. Blakemore in 1975, and this led to the discovery of a wide
collection of microorganisms with similar features i.e., the ability to internalize Fe and convert it into magnetic nanoparticles,
in the form of either magnetite (Fe3O4) or greigite (Fe3S4). Studies showed that these particles are highly crystalline, monodisperse, bioengineerable and have high magnetism that
is comparable to those made by advanced synthetic methods, making them candidate materials for a broad range of bio-applications.
In this review article, the history of the discovery of MTB and subsequent efforts to elucidate the mechanisms behind the
magnetosome formation are briefly covered. The focus is on how to utilize the knowledge gained from fundamental studies to
fabricate functional MTB nanoparticles (MTB-NPs) that are capable of tackling real biomedical problems. |
| |
Keywords: | Magnetotactic bacteria (MTB) magnetosome bio-application magnetic resonance imaging (MRI) |
本文献已被 SpringerLink 等数据库收录! |
|