Hypotensive effects of [D-Tyr27,36, D-Thr32]Neuropeptide Y (27-36) |
| |
Authors: | AK Roscoe SM Leach JW Nyce WR Wooles |
| |
Affiliation: | Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858, USA. |
| |
Abstract: | An analogue of the 10 C-terminal amino acids of neuropeptide Y (NPY) containing three D-isomeric substitutions (27-36-D) has been synthesized and its cardiovascular activity studied in Sprague-Dawley (SD) and spontaneously hypertensive (SHR) rats. Intravenous administration of 1000 nmol/kg 27-36-D decreases MAP in SHR (-59.9 +/- 5.0 mmHg) and SD rats (-44.4 +/- 4.7 mmHg). The hypotension produced by 1000 nmol/kg 27-36-D diminished by 71.2% following pretreatment with the histamine receptor antagonist diphenhydramine, although histamine depletion with compound 48/80 does not significantly alter this hypotension. These data suggest that NPY (27-36)-D produces a profound and sustained hypotension in two strains of rat which is partially attributable to activity at histamine receptors. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|