Measuring morbidity of children in the community: a comparison of interview and diary data |
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Authors: | MA Bruijnzeels M Foets JC van der Wouden A Prins WJ van den Heuvel |
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Affiliation: | Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki 701-0192, Japan. |
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Abstract: | We investigated mechanisms for enhancement of peroxynitrite (OONO-; 5 microM)-evoked [3H] gamma-aminobutyric acid (GABA) release. Hydroxyl radical scavengers such as N,N'-dimethylthiourea (DMTU), mannitol, and uric acid, significantly increased OONO--evoked [3H]GABA release, whereas urea showed no effects on the release. Removal of Ca2+ from incubation buffer abolished the enhancement of the release by DMTU, although DMTU showed no effects on the basal release with and without Ca2+ in extracellular space. These results indicate that hydroxyl radical scavengers facilitate OONO--evoked [3H]GABA release dependent on Ca2+. |
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