Use of a Desk-Top Computer in a Search-Type Optimization of Tablet Formulations

The use of a desk-top computer in the field of formulation and process optimization is described. To illustrate an application of this technique, a series of tablets has been prepared according to a classical optimization design to determine the optman levels of process variables which meet pre-established specifications for product variables (hardness, thickness, etc.) based on second order polynomial predictor equations for each measured parameter.