Use of a Desk-Top Computer in a Search-Type Optimization of Tablet Formulations |
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Authors: | G. K. B. Down R. A. Miller S. k. Chopra J. F. Millar |
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Affiliation: | a Pharmacy Research and Development Merck Frosst Laboratories Kirkland, Quebec, Canada |
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Abstract: | The use of a desk-top computer in the field of formulation and process optimization is described. To illustrate an application of this technique, a series of tablets has been prepared according to a classical optimization design to determine the optman levels of process variables which meet pre-established specifications for product variables (hardness, thickness, etc.) based on second order polynomial predictor equations for each measured parameter. |
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