| 基于乙二胺四乙酸酐和丁二胺的pH敏感水凝胶的合成与表征 |
| |
| 引用本文： | 邱奎,孙姣霞,彭辉,韩志伟,罗彦凤.基于乙二胺四乙酸酐和丁二胺的pH敏感水凝胶的合成与表征[J].高分子材料科学与工程,2009(8). |
| |
| 作者姓名： | 邱奎 孙姣霞 彭辉 韩志伟 罗彦凤 |
| |
| 作者单位： | 生物流变科学与技术教育部重点实验室(重庆大学)重庆大学生物工程学院生物材料与仿生工程研究中心;重庆科技学院化学化工学院; |
| |
| 基金项目： | 重庆市自然科学基金资助项目(CSTC2006BB5010) |
| |
| 摘 要： | 以乙二胺四乙酸酐(EDTAD)和丁二胺(BDA)为原料,通过酸酐的N-酰化开环反应制备侧链含羧基的直链聚合物(pEDTAD-BDA);然后以二环己基碳二亚胺(DCC)活化pEDTAD-BDA中的羧基,以BDA为交联剂,制得单体间连接全部为酰胺键、侧链只含羧基的交联网络聚合物BDA-crosslinked-EDTAh-BDA。采用氢核磁共振(1H-NMR)、碳核磁共振(13C-NMR)和茚三酮显色法对pEDTAD-BDA的结构和数均分子量进行了表征。pH敏感性测试表明,BDA-crosslinked-pEDTAD-BDA在pH=12介质中的溶胀率约为pH=3和pH=7介质中溶胀率的5倍,表现出敏锐的pH响应性。该网络聚合物可望成为一种集完全可降解性、良好生物相容性和pH敏感性于一身的医用水凝胶材料。
|
| 关 键 词： | 乙二胺四乙酸酐 丁二胺 水凝胶 pH敏感性 生物可降解性 |
Synthesis and Characterization of a Biodegradable pH-Sensitive Hydrogel Based on Ethylenediamine Tetraacetic Dianhydride and Butanediamine |
| |
| QIU Kui,SUN Jiao-xia,PENG Hui,HAN Zhi-wei,LUO Yan-feng,Ministry of Education,Research Center of Bioinspired Material Science , Engineering,College of Bioengineering,Chongqing University,Chongqing ,China,.School of Chemistry &Chemical Engineering,Chongqing University of Science , Technology,Chongqing ,China.Synthesis and Characterization of a Biodegradable pH-Sensitive Hydrogel Based on Ethylenediamine Tetraacetic Dianhydride and Butanediamine[J].Polymer Materials Science & Engineering,2009(8). |
| |
| Authors: | QIU Kui SUN Jiao-xia PENG Hui HAN Zhi-wei LUO Yan-feng Ministry of Education Research Center of Bioinspired Material Science Engineering College of Bioengineering Chongqing University Chongqing China School of Chemistry &Chemical Engineering Chongqing University of Science Technology Chongqing China |
| |
| Affiliation: | QIU Kui1,2,SUN Jiao-xia1,PENG Hui1,HAN Zhi-wei1,LUO Yan-feng1(1.Key Lab of Biorheological Science and Technology(Chongqing University),Ministry of Education,Research Center of Bioinspired Material Science and Engineering,College of Bioengineering,Chongqing University,Chongqing 400030,China,2.School of Chemistry &Chemical Engineering,Chongqing University of Science and Technology,Chongqing 401331,China) |
| |
| Abstract: | A novel degradable pH-sensitive hydrogel was synthesized from ethylenediamine tetraacetic dianhydride(EDTAD) and butanediamine(BDA): firstly,EDTAD reacted with butanediamine(BDA) through N-acrylation of anhydride groups in EDTAD with amino groups in BDA,producing a linear copolymer containing pendant carboxyl groups(pEDTAD-BDA);then,the carboxyl groups in pEDTAD-BDA were activated by N,N'-dicyclohexylcarbodiimide(DCC) and thereafter condensed with BDA as crosslinking agent,yielding the desired network polym... |
| |
| Keywords: | ethylenediamine tetraacetic dianhydride butanediamine hydrogel pH-sensitive biodegradable |
| 本文献已被 CNKI 等数据库收录！ |
|
