| L-薄荷基甲醛的合成 |
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| 引用本文： | 阳年发.L-薄荷基甲醛的合成[J].精细化工,2010,27(6). |
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| 作者姓名： | 阳年发 |
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| 作者单位： | 湘潭大学,化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南,湘潭,411105 |
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| 基金项目： | 国家自然科学基金，湖南省自然科学基金 |
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| 摘 要： | 薄荷基氯格氏试剂与N,N-二甲基甲酰胺(DMF)在四氢呋喃中反应,一步合成了L-薄荷基甲醛。重点探讨了物料比、反应温度和反应时间对反应收率的影响。最优的反应条件是薄荷基氯格氏试剂与DMF以1∶1.2的摩尔比在20℃反应4h。在最优反应条件下,产率为42.6%,产物没有立体异构体。
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| 关 键 词： | 二甲基甲酰胺 L-薄荷基氯 立体选择性 L-薄荷基甲醛 精细化工中间体 |
| 收稿时间： | 2/4/2010 12:00:00 AM |
| 修稿时间： | 2010/3/27 0:00:00 |
Synthesis of L-menthylformaldehyde |
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| Yang Nian-fa.Synthesis of L-menthylformaldehyde[J].Fine Chemicals,2010,27(6). |
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| Authors: | Yang Nian-fa |
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| Affiliation: | College of Chemistry, Xiangtan University |
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| Abstract: | L-menthylformaldehyde was synthesized by the reaction of the Grignard reagent derived from menthyl chloride with N,N-dimethylformamide (DMF) in tetrahydrofuran by one-step process. The influence of the material ratio, reaction temperature and reaction time on the yield of the product had been investigated. The optimal reaction condition was the Grignard reagent reaction with 1.2 equivalent of DMF at 20oC for 4 hours. Under optimal reaction condition, the yield was 42.6% and no stereoisomer yielded. |
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| Keywords: | dimethyl formamide L-menthyl chloride stereoselectivity L-menthylformaldehyde fine chemical intermediates |
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