环境激素邻苯二甲酸丁基苄酯的动力学

采用同位素标记方法示踪环境激素邻苯二甲酸丁基苄酯的生物转运过程,用NDST21动力学处理软件判断房室模型,建立邻苯二甲酸丁基苄酯的数学模型,计算各种参数.实验结果表明:3H-BBP经口染毒后被迅速吸收,5 min即在血中检测出,0.5 h达高峰,并呈一级动力学线性过程,符合二室开放模型;测得吸收半衰期约为13 min,分布半衰期约为25 min,消除半衰期约为7 h,说明该化合物的吸收和分布较快、消除较慢;3H-BBP的主要排泄途径是从尿和粪中排泄,在4 d之内从尿和粪累计排泄量占染毒量80%左右.

Dynamics of environmental hormone butylbenzyl phthalate

To study the biotransmission of environmental hormone butylbenzyl phthalate by isotope-labeling method, pharmacokinetic compartment model was evaluated by NDST21 software and mathematical model of butylbenzyl phthalate was set up to evaluate parameters. The results show ^3H-BBP is absorbed rapidly and detected in blood after 5 min, then its concentration reaches top at 0. 5 h. First-order linear equation and twocompartment open model are gained. The half life of absorption, distribution and elimination is respectively about 13 min, 25 min and 7 h, which indicates the absorption and distribution of this is compound quick and elimination is slow. ^3H-BBP is mainly excreted by urine and feces, and the excrement of ^3H-BBP accounts for 80% of total dose within 4 days.