| 3-氨基-7,8-二甲氧基香豆素的合成路线改进 |
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| 引用本文： | 陈琳,周晔,谭培汉,庄泽荣. 3-氨基-7,8-二甲氧基香豆素的合成路线改进[J]. 广州化工, 2014, 0(10): 55-57 |
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| 作者姓名： | 陈琳 周晔 谭培汉 庄泽荣 |
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| 作者单位： | 广东药学院,广东广州510006 |
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| 基金项目： | 广东省科技计划项目（2010B060900084;2012B061700040）. |
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| 摘 要： | 3-氨基-7,8-二甲氧基香豆素及其衍生物是一类具有潜在药用价值的重要化合物。本文对其合成路线进行了研究改进,以2,3,4-三甲氧基苯甲醛为起始原料,通过甲氧基还原及Knoevenagel缩合反应,获得目标产物并通过1H-NMR、13C-NMR及IR检测确证。合成路线操作简便、条件温和、环境友好。水解反应较佳工艺条件为:反应pH=3~4;反应温度(75±2)℃;反应时间30 min。
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| 关 键 词： | -氨基- -二甲氧基香豆素 合成改进 水解 |
Improved-Synthesis Route of 3-Amino-7,8-Dimethoxy-2H-Chromen-2-One |
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| Affiliation: | CHEN Lin, ZHOU Ye, TAN Pei -han, ZHUANG Ze - rong (Guangdong Pharmaceutical University, Guangdong Guangzhou 510006, China) |
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| Abstract: | 3 -Amino -7,8 -dimethoxy -2H- chromen -2 -one and its derivatives were a potential medicinal value may be an important compounds. The title product was synthesized from 2,3,4 - trimethoxybenzaldehyde by the methoxy reduction and Knoevenagel reaction. Its structure was verified by 1H -NMR, 13C -NMR, and IR analysis. The procedure had the advantages of convenient operations, mild reaction conditions and environment friendly. The experimental results showed that the optimum conditions for the hydrolysis reaction were reaction pH = 3 - 4, reaction temperature （75 ± 2） ℃ and reaction time 30 min. |
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| Keywords: | 3 - Amino - 7, 8 - dimethoxy - 2H - chromen - 2 - one synthetic route improvement hydrolysis |
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