Fatty acid composition at the 2-position of ether-linked and diacyl ethanolamine and choline phosphoglycerides of human brain tumors |
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Authors: | Daniel H Albert Carl E Anderson |
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Affiliation: | (1) Department of Biochemistry and Nutrition, School of Medicine, University of North Carolina, 27514 Chapel Hill, NC;(2) Present address: Department of Biochemistry, Vanderbilt University, 37232 Nashville, TN |
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Abstract: | The acyl composition of ethanolamine and choline phosphoglycerides from a series of human brain tumors was determined and
compared to that of normal human gray matter. Six glioblastomas, one astrocytoma, one oligodendroglioma, and one meningioma
were analyzed. The total fatty acid composition of ethanolamine phosphoglycerides generally had a higher percentage of 18∶1,
18∶2ω6, and 22∶5ω3 and a lower percentage of 22∶6ω3 than that of normal gray matter. Choline phosphoglycerides from the tumors
also contained a higher than normal percentage of 18∶2ω6. Separate analysis of the acyl groups at the 2 position of the diacyl
and ether-linked components of the phosphoglycerides revealed that the diacyl component of ethanolamine phosphoglyceride from
the tumors had lower than normal amount of 22∶6ω3 and a higher than normal amount of 18∶1 and 18∶2ω6. The acyl composition
of ether-linked ethanolamine phosphoglycerides genearally contained a higher percentage of 20∶4ω6 and a lower percentage of
18∶1 compared to the corresponding fraction from normal gray matter. The astrocytoma analyzed had fatty acid profiles similar
to those of the control with the exception of a greater 18∶2ω6 content. These data demonstrate that the composition of the
acyl moiety at the 2 position of diacyl and ether-linked phosphoglycerides of brain tumors differs from the corresponding
component from normal gray matter and that the ether-linked ethanolamine phosphoglycerides provide an important pool of polyunsaturated
fatty acids from brain tumor phospholipids. |
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