明胶微球载药及其体外释放性能研究

以阿司匹林为药物模型分子，制备了载阿司匹林明胶微球。SEM研究表明，明胶微球在载药后，表面结构变得更为紧实。载药性能探讨表明，当阿司匹林的投药量为16mg时，明胶微球的载药性能较优（载药量为7．3％，包封率为57．5％）。对明胶微球在人工体液中的释药性能研究显示，载阿司匹林明胶微球具有良好的缓释性能。由于具有较大的酸性和胃蛋白酶的存在，微球在人工胃液中药物释放效率较高，在人工胃液和人工肠液中药物的释放率分别为40％和28％，且一级动力学模型对微球的体外药物释放情况拟合度较高。

Preparation of drug loaded gelatin microspheres and release behaviour in vitro

In this study,the aspirin loaded gelatin microspheres were prepared usmg aspirin as me orug model molecules. The SEM result showed that the surface structure of microspheres was more corn pact after drug loading. The drug loading property of microspheres was investigated, which showed that the drug loading property （drug loading capacity was 7. 3% and encapsulation efficiency was 57.5%） was optimum as the aspirin dosage was 16 mg. The drug release properties of the gelatin microspheres in artificial body fluid were explored, good sustained release properties of gelatin microspheres were observed. And the release efficiency is much higher in the artificial gastric juice due to the larger presence of acid and pepsin, drug release rates in artificial gastric juice and artificial intestinal fluid were 28% and 40% respectively. The first order dynamic model could describe the release process in vitro perfectly.